Hemostasis and coagulation at a hematocrit of 0.85: functional consequences of erythrocytosis
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word count: 239 Total text word count: 3790 Supported by a grant of the Department of Anesthesiology and Resuscitation, Shinshu University (KFW) and a faculty grant of the University Lübeck (KFW). Topic: Hemostasis, Thrombosis and Vascular Biology * Both authors contributed equally to the study # Present address: Department of Anesthesiology and Resuscitation, Shinshu University, Japan § Present address: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA $ Present address: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA Corresponding author: Klaus F. Wagner, M.D. Department of Anesthesiology, University Lübeck Ratzeburger Allee 160, D-23538 Lübeck Email: [email protected] Copyright (c) 2003 American Society of Hematology Blood First Edition Paper, prepublished online February 6, 2003; DOI 10.1182/blood-2002-09-2814 only. For personal use at PENN STATE UNIVERSITY on February 20, 2013. bloodjournal.hematologylibrary.org From
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Hemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis
We have generated a transgenic mouse line that reaches a hematocrit concentration of 0.85 due to constitutive overexpression of human erythropoietin in an oxygen-independent manner. Unexpectedly, this excessive erythrocytosis did not lead to thrombembolic complications in all investigated organs at any age. Thus, we investigated the mechanisms preventing thrombembolism in this mouse model. Bloo...
متن کاملHemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis.
We have generated a transgenic mouse line that reaches a hematocrit concentration of 0.85 due to constitutive overexpression of human erythropoietin in an oxygen-independent manner. Unexpectedly, this excessive erythrocytosis did not lead to thrombembolic complications in all investigated organs at any age. Thus, we investigated the mechanisms preventing thrombembolism in this mouse model. Bloo...
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